Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14406911 | 0.86 | NTRK1 (0.44) | NTRK1MAP2K1RPS6KA5AXL | |
| SCHEMBL27934700 | 0.86 | NTRK1 (0.49) | MAP3K7TAB1NTRK1MAP2K1RPS6KA5 | |
| SCHEMBL15173466 | 0.84 | ALDH1A1 (0.43) | NTRK1MAP2K1RPS6KA5AXL | |
| SCHEMBL29589055 | 0.84 | ALDH1A1 (0.43) | NTRK1MAP2K1RPS6KA5AXL | |
| SCHEMBL21713015 | 0.83 | MAP2K1 (0.59) | MAP2K1AXL | |
| Hydrochloric Acid SCHEMBL30131065 | 0.83 | NTRK1 (0.42) | NTRK1MAP2K1RPS6KA5AXL | |
| SCHEMBL16797928 | 0.82 | MAP4K1 (0.45) | NTRK1MAP2K1ABL1JAK3CLK4 | |
| SCHEMBL30996123 | 0.82 | NTRK1 (0.40) | MAP3K7TAB1NTRK1MAP2K1JAK2 | |
| SCHEMBL31070093 | 0.82 | MAP2K1 (0.43) | MAP3K7TAB1NTRK1MAP2K1RPS6KA5 | |
| SCHEMBL28202369 | 0.81 | NTRK1 (0.44) | MAP3K7TAB1NTRK1MAP2K1RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143024-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2009-11-26 | — | — | WO | disclosed |