Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 14/20 | 0.63 |
| ▸ | HSP90AB1 | P08238 | 12/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494977 | 0.87 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1OPRL1 | |
| SCHEMBL13627466 | 0.86 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627478 | 0.86 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627491 | 0.85 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627517 | 0.85 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627473 | 0.85 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627499 | 0.85 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627483 | 0.85 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL13627516 | 0.85 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627493 | 0.84 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |