Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 15/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494977 | 0.88 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627468 | 0.86 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627499 | 0.86 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1SUV39H2 | |
| SCHEMBL13627466 | 0.85 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627504 | 0.83 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627494 | 0.82 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1ROCK2PRKD3CSF1R | |
| SCHEMBL13627477 | 0.82 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1SUV39H2 | |
| SCHEMBL13627491 | 0.81 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627517 | 0.81 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1ROCK2PRKD3CSF1R | |
| SCHEMBL13627473 | 0.81 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |