Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13627481 | 0.90 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1NPY2R | |
| SCHEMBL13627498 | 0.89 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627495 | 0.89 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1DRD2HTR2AHTR1A | |
| SCHEMBL13627491 | 0.84 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1DRD2NPY2R | |
| SCHEMBL13627487 | 0.83 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627519 | 0.83 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627503 | 0.82 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627505 | 0.81 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627486 | 0.80 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1DRD2HTR1A | |
| SCHEMBL13627483 | 0.80 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |