Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.49 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13627481 | 0.91 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1ALDH1A1KDM4ENPSR1 | |
| SCHEMBL13627519 | 0.90 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1ALDH1A1NPSR1MAPT | |
| SCHEMBL13627503 | 0.89 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627505 | 0.89 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627482 | 0.87 | ALDH1A1 (0.54) | HSP90AA1HSP90AB1ALDH1A1KDM4ENPSR1 | |
| SCHEMBL13627501 | 0.87 | ALDH1A1 (0.46) | HSP90AA1HSP90AB1ALDH1A1GAAMAPT | |
| SCHEMBL13627494 | 0.86 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13627483 | 0.86 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1ALDH1A1KDM4EMAPT | |
| SCHEMBL13627491 | 0.84 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL13627475 | 0.84 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |