Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 17/20 | 0.48 |
| ▸ | CCR5 | P51681 | 13/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13627815 | 0.94 | CCR2 (0.48) | CCR2CCR5KCNH2 | |
| SCHEMBL13628373 | 0.84 | CCR2 (0.44) | CCR2KCNH2 | |
| SCHEMBL13627581 | 0.84 | NAMPT (0.39) | KCNH2 | |
| SCHEMBL13627656 | 0.82 | CCR2 (0.44) | CCR2CCR5KCNH2 | |
| SCHEMBL13627813 | 0.80 | CCR2 (0.36) | CCR2CCR5KCNH2PPARGPPARA | |
| SCHEMBL13741754 | 0.78 | CCR2 (0.76) | CCR2CCR5KCNH2 | |
| SCHEMBL4146542 | 0.78 | CCR2 (0.76) | CCR2CCR5KCNH2 | |
| SCHEMBL13627585 | 0.76 | CCR2 (0.47) | CCR2CCR5KCNH2 | |
| SCHEMBL4137680 | 0.71 | CCR2 (0.78) | CCR2CCR5KCNH2 | |
| SCHEMBL4138600 | 0.71 | CCR2 (0.78) | CCR2CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618970-B2 | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors | INCYTE CORPORATION (US) | 2009-11-17 | — | — | US | disclosed |