Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3737335 | 1.00 | MAPT (0.60) | MAPTRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL3737334 | 1.00 | MAPT (0.60) | MAPTRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL11345591 | 0.94 | MAPT (0.53) | MAPTRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL11568552 | 0.86 | NPC1 (0.66) | MAPTRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL12264384 | 0.86 | SMN1; SMN2 (0.62) | MAPTRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL2547131 | 0.86 | SMN1; SMN2 (0.62) | MAPTRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL20291763 | 0.85 | MAPT (0.58) | MAPTRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL18548859 | 0.85 | MAPT (0.58) | MAPTRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL15164801 | 0.85 | MAPT (0.58) | MAPTRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL10862595 | 0.83 | MAPT (0.58) | MAPTRAB9ANPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612080-B2 | GTPase inhibitors and use thereof for controlling platelet hyperactivity | CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2009-11-03 | — | — | US | disclosed |
| US-7517890-B2 | GTPase inhibitors and methods of use | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2009-04-14 | — | — | US | disclosed |