Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.66 |
| ▸ | RAB9A | P51151 | 9/20 | 0.66 |
| ▸ | MAPT | P10636 | 8/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | TGM2 | P21980 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.50 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11345591 | 0.91 | MAPT (0.53) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL19379963 | 0.86 | RAB9A (0.70) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18587028 | 0.86 | RAB9A (0.70) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18587029 | 0.86 | RAB9A (0.70) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10862976 | 0.86 | MAPT (0.58) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10558301 | 0.86 | MAPT (0.58) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10558287 | 0.86 | MAPT (0.58) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3737335 | 0.86 | MAPT (0.60) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3737334 | 0.86 | MAPT (0.60) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13628941 | 0.86 | MAPT (0.60) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002231-A1 | 1-N-aryl-1,4-dihydropyridines, process for their preparation and their pharmaceutical application | BAYER AG (DE) | 1979-06-13 | — | — | EP | disclosed |