Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628991 | 0.90 | GRM4 (0.48) | GRM4 | |
| SCHEMBL30572129 | 0.87 | ALB (0.58) | GRM4 | |
| SCHEMBL1253711 | 0.87 | ALB (0.58) | GRM4 | |
| SCHEMBL12727144 | 0.85 | TRPV1 (0.47) | TRPV1 | |
| SCHEMBL2619783 | 0.85 | ALB (0.47) | GRM4TRPV1 | |
| SCHEMBL10287531 | 0.85 | TRPV1 (0.45) | GRM4TRPV1 | |
| SCHEMBL13628988 | 0.84 | TRPV1 (0.54) | GRM4TRPV1 | |
| SCHEMBL12727302 | 0.83 | ALB (0.59) | TRPV1ADORA3 | |
| SCHEMBL2619598 | 0.83 | GRM4 (0.47) | GRM4TRPV1 | |
| SCHEMBL12727187 | 0.82 | MEN1 (0.56) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | GRM4 1839/4885TRPV1 4209/4885ADORA3 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.