Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628989 | 0.90 | GRM4 (0.48) | GRM4 | |
| SCHEMBL30572102 | 0.89 | ALB (0.53) | GRM4ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL2611890 | 0.89 | ALB (0.53) | GRM4ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13628992 | 0.86 | ALDH1A1 (0.47) | GRM4ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL12214931 | 0.86 | GRM4 (0.51) | GRM4ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL10287464 | 0.83 | MEN1 (0.46) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL12214930 | 0.83 | HPGDS (0.56) | GRM4ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL2619399 | 0.81 | HCAR3 (0.47) | GRM4ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL12727284 | 0.80 | CYP2C19 (0.40) | GRM4ALDH1A1NPC1RAB9A | |
| SCHEMBL12727285 | 0.80 | CYP2C19 (0.40) | GRM4ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | GRM4 1839/4885ALDH1A1 2407/4885MEN1 468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.