Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14413034 | 0.82 | POLB (0.58) | POLBLMNASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL4309324 | 0.80 | SMN1; SMN2 (0.67) | POLBSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL16892193 | 0.80 | GAA (0.39) | POLBLMNASMN1; SMN2REV1ALDH1A1 | |
| SCHEMBL23541545 | 0.80 | SMN1; SMN2 (0.49) | POLBLMNASMN1; SMN2REV1ALDH1A1 | |
| SCHEMBL13804389 | 0.80 | POLB (0.58) | POLBLMNASMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL12788462 | 0.79 | LMNA (0.74) | POLBLMNASMN1; SMN2REV1ALDH1A1 | |
| SCHEMBL12513713 | 0.79 | KMT2A (0.64) | LMNASMN1; SMN2REV1ALDH1A1MAPK1 | |
| SCHEMBL12311362 | 0.78 | POLB (0.65) | POLBLMNASMN1; SMN2KMT2AACACB | |
| SCHEMBL12895864 | 0.78 | POLB (0.65) | POLBLMNAALDH1A1MAPK1KDM4E | |
| SCHEMBL190928 | 0.78 | CYP1A2 (0.48) | SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |