SCHEMBL1362999

SCHEMBL1362999

Cc1c(O)ccc(Cl)c1C.Cc1ccc(Cl)c(O)c1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.40
ATM Q13315 1/20 0.40
CYP3A4 P08684 2/20 0.37
MAPK1 P28482 1/20 0.37
SHBG P04278 1/20 0.34
ESR2 Q92731 3/20 0.33
ESR1 P03372 2/20 0.33
DPP4 P27487 1/20 0.32
HTR1D P28221 1/20 0.32
HTR1B P28222 1/20 0.32
SCN5A Q14524 1/20 0.32
TDP1 Q9NUW8 3/20 0.31
TSHR P16473 2/20 0.31
HSD17B10 Q99714 2/20 0.31
TP53 P04637 1/20 0.31
ALDH1A1 P00352 1/20 0.31
POLB P06746 1/20 0.31
RECQL P46063 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
TYR P14679 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL34164 0.87 DPP4 (0.39) TRPA1ATMCYP3A4MAPK1DPP4
SCHEMBL28812975 0.87 DPP4 (0.39) TRPA1ATMCYP3A4MAPK1DPP4
SCHEMBL335595 0.85 CYP3A4 (0.48) TRPA1ATMCYP3A4MAPK1SHBG
SCHEMBL29566553 0.85 CYP3A4 (0.48) TRPA1ATMCYP3A4MAPK1SHBG
Water SCHEMBL29243256 0.83 CYP3A4 (0.46) TRPA1ATMCYP3A4MAPK1SHBG
SCHEMBL3790032 0.83 CYP3A4 (0.46) TRPA1ATMCYP3A4MAPK1SHBG
SCHEMBL1867458 0.82 TRPA1 (0.65) TRPA1ATMMAPK1SHBGESR2
Alcohol SCHEMBL28660521 0.79 DPP4 (0.34) TRPA1ATMCYP3A4MAPK1ESR2
SCHEMBL11699414 0.78 DPP4 (0.42) CYP3A4MAPK1ESR2ESR1DPP4
SCHEMBL10340010 0.76 GAA (0.32) TRPA1ATMCYP3A4MAPK1DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110287193-A1 APPARATUS AND METHOD FOR TREATING AN OBJECT NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2011-11-24 US disclosed
EP-2345312-A1 APPARATUS AND METHOD FOR TREATING AN OBJECT Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO (NL) 2011-07-20 EP disclosed