Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.45 |
| ▸ | CHUK | O15111 | 2/20 | 0.41 |
| ▸ | INSR | P06213 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2199592 | 0.89 | BRD4 (0.46) | BRD4CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL2197555 | 0.85 | BRD4 (0.49) | BRD4CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL2200493 | 0.84 | BRD4 (0.46) | BRD4CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL2196927 | 0.84 | CDC7 (0.54) | BRD4CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL2198470 | 0.83 | BRD4 (0.47) | BRD4CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL12509787 | 0.82 | KMT2A (0.50) | BRD4CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL2199883 | 0.82 | CHEK1 (0.45) | BRD4CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL2195870 | 0.81 | KDM4E (0.50) | BRD4CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL2199427 | 0.81 | MAPT (0.55) | BRD4CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL2197053 | 0.81 | BRD4 (0.47) | BRD4IKBKBPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116530-A1 | NOVEL PYRROLE DERIVATIVE HAVING UREIDE GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-11 | — | — | EP | disclosed |