Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431906 | 0.90 | CYP2E1 (0.35) | NR1H4ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL2431909 | 0.90 | CYP2E1 (0.35) | NR1H4ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL14043164 | 0.83 | CYP2E1 (0.39) | NPC1RAB9A | |
| SCHEMBL13630952 | 0.81 | ALDH1A1 (0.48) | NR1H4ALDH1A1CASP3SENP7SENP6 | |
| SCHEMBL2427730 | 0.79 | CYP2E1 (0.35) | NR1H4ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL2427732 | 0.79 | CYP2E1 (0.35) | NR1H4ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL10264611 | 0.77 | CYP2E1 (0.40) | NR1H4ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL15124246 | 0.77 | CYP2E1 (0.40) | NR1H4ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL671182 | 0.76 | ALDH1A1 (0.41) | NR1H4ALDH1A1TP53MEN1KMT2A | |
| SCHEMBL4344584 | 0.76 | ALDH1A1 (0.41) | NR1H4ALDH1A1TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090274655-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090274655-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS | EIF2AK2, HAVCR2, GTF3C2 | NR1H4 1468/4885ALDH1A1 860/4885CASP3 1076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.