Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13434238 | 1.00 | REN (0.52) | RENCYP3A4ADRA1AKCNH2HTR1A | |
| SCHEMBL13434234 | 1.00 | REN (0.52) | RENCYP3A4ADRA1AKCNH2HTR1A | |
| SCHEMBL3487499 | 0.98 | REN (0.51) | RENCYP3A4ADRA1AKCNH2HTR1A | |
| SCHEMBL3488263 | 0.95 | REN (0.53) | RENCYP3A4ADRA1AKCNH2HTR1A | |
| SCHEMBL3488941 | 0.88 | REN (0.48) | RENCYP3A4ADRA1AKCNH2HTR1A | |
| SCHEMBL3487423 | 0.88 | REN (0.53) | RENADRA1AKCNH2HTR1AADRA1D | |
| SCHEMBL3488892 | 0.88 | REN (0.53) | RENADRA1AKCNH2HTR1AADRA1D | |
| SCHEMBL13434465 | 0.87 | REN (0.44) | RENCYP3A4ADRA1AKCNH2HTR1A | |
| SCHEMBL13434532 | 0.86 | REN (0.53) | RENCYP3A4ADRA1AKCNH2HTR1A | |
| SCHEMBL3488928 | 0.85 | NPC1 (0.50) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119702-A1 | AMIDE DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2009-11-18 | — | — | EP | disclosed |