Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.43 |
| ▸ | F10 | P00742 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505244 | 0.92 | LMNA (0.44) | LMNATP53ENPP2F10 | |
| SCHEMBL4504155 | 0.88 | LMNA (0.44) | LMNATP53ENPP2F10POLB | |
| SCHEMBL4505024 | 0.88 | F10 (0.54) | LMNATP53ENPP2F10 | |
| SCHEMBL4492429 | 0.86 | LMNA (0.50) | LMNATP53ENPP2F10 | |
| SCHEMBL4503744 | 0.82 | F10 (0.49) | LMNATP53ENPP2F10POLB | |
| SCHEMBL13632177 | 0.82 | TP53 (0.46) | LMNATP53F10POLB | |
| SCHEMBL4506998 | 0.81 | F10 (0.53) | LMNATP53F10 | |
| SCHEMBL3293115 | 0.81 | LMNA (0.51) | LMNATP53F10POLB | |
| SCHEMBL4506177 | 0.80 | F10 (0.54) | LMNATP53ENPP2F10 | |
| SCHEMBL4500589 | 0.80 | LMNA (0.46) | LMNATP53ENPP2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615549-B2 | Substituted pyrrolidinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |
| US-7615549-B2 | Substituted pyrrolidinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |