Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13632954 | 0.84 | NAMPT (0.45) | CYP17A1BRD4CREBBPNAMPTBCL2 | |
| SCHEMBL13633132 | 0.83 | BRD4 (0.48) | CYP17A1BRD4CREBBPRXFP1HDAC1 | |
| SCHEMBL24908194 | 0.82 | CYP17A1 (0.50) | CYP17A1BRD4CREBBPRXFP1HDAC1 | |
| SCHEMBL13754832 | 0.76 | CYP17A1 (0.64) | CYP17A1BRD4CREBBPHDAC1HDAC3 | |
| SCHEMBL29029431 | 0.75 | HDAC3 (0.56) | CYP17A1BRD4CREBBPRXFP1HDAC1 | |
| SCHEMBL13633012 | 0.75 | CYP17A1 (0.40) | CYP17A1RXFP1BRD9KDM4E | |
| SCHEMBL18535719 | 0.74 | BRD9 (0.50) | BRD4CREBBPRXFP1BRD9KDM4E | |
| SCHEMBL3785736 | 0.74 | BRD4 (0.53) | CYP17A1BRD4CREBBPRXFP1HDAC1 | |
| SCHEMBL3786623 | 0.74 | CHRM3 (0.46) | CYP17A1BRD4CREBBPRXFP1BRD9 | |
| SCHEMBL31671045 | 0.74 | CYP17A1 (0.76) | CYP17A1BRD4CREBBPHDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | CYP17A1 3568/4885BRD4 342/4885CREBBP 2369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.