Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.60 |
| ▸ | DDX3X | O00571 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ULK1 | O75385 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29568967 | 0.86 | PTGS1 (0.72) | PTGS1DDX3XALDH1A1CNR1SMN1; SMN2 | |
| SCHEMBL308208 | 0.86 | PTGS1 (0.72) | PTGS1DDX3XALDH1A1CNR1SMN1; SMN2 | |
| SCHEMBL8403932 | 0.86 | PTGS1 (0.72) | PTGS1DDX3XALDH1A1CNR1SMN1; SMN2 | |
| SCHEMBL31171978 | 0.86 | PTGS1 (0.72) | PTGS1DDX3XALDH1A1CNR1SMN1; SMN2 | |
| SCHEMBL28136378 | 0.84 | HDAC1 (0.63) | SMN1; SMN2MEN1KMT2AKCNK3KCNK9 | |
| Hydrochloric Acid SCHEMBL11740733 | 0.84 | PTGS1 (0.70) | PTGS1DDX3XALDH1A1CNR1SMN1; SMN2 | |
| SCHEMBL2126328 | 0.82 | PTGS1 (0.68) | PTGS1DDX3XALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL394748 | 0.81 | KCNK3 (0.76) | PTGS1DDX3XALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL29568808 | 0.81 | PTGS1 (0.79) | PTGS1DDX3XALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8399784 | 0.81 | PTGS1 (0.79) | PTGS1DDX3XALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | PTGS1 1501/4885DDX3X 3846/4885ALDH1A1 2511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.