SCHEMBL394748

SCHEMBL394748

Nc1cccc(NC(=O)c2ccccc2)c1

nearest known ligand 0.76

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 6/20 0.76
KCNK9 Q9NPC2 5/20 0.76
PTGS1 P23219 3/20 0.69
SIRT1 Q96EB6 1/20 0.67
RAB9A P51151 4/20 0.65
NPC1 O15118 3/20 0.65
HPGD P15428 1/20 0.65
DDX3X O00571 1/20 0.65
MEN1 O00255 4/20 0.63
KMT2A Q03164 4/20 0.63
TP53 P04637 1/20 0.63
ALDH1A1 P00352 2/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
POLB P06746 1/20 0.61
NLRP3 Q96P20 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8399784 0.93 PTGS1 (0.79) KCNK3KCNK9PTGS1SIRT1RAB9A
SCHEMBL29568808 0.93 PTGS1 (0.79) KCNK3KCNK9PTGS1SIRT1RAB9A
SCHEMBL29568967 0.91 PTGS1 (0.72) KCNK3KCNK9PTGS1DDX3XMEN1
SCHEMBL308208 0.91 PTGS1 (0.72) KCNK3KCNK9PTGS1SIRT1DDX3X
SCHEMBL31171978 0.91 PTGS1 (0.72) KCNK3KCNK9PTGS1SIRT1DDX3X
SCHEMBL8403932 0.91 PTGS1 (0.72) KCNK3KCNK9PTGS1DDX3XMEN1
SCHEMBL1337455 0.90 PTPN1 (0.67) KCNK3KCNK9PTGS1RAB9ANPC1
Hydrochloric Acid SCHEMBL11740733 0.89 PTGS1 (0.70) KCNK3KCNK9PTGS1DDX3XMEN1
SCHEMBL29672230 0.89 PTGS1 (0.74) KCNK3KCNK9PTGS1SIRT1RAB9A
SCHEMBL1352405 0.89 PTGS1 (0.68) KCNK3KCNK9PTGS1SIRT1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 277 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101273009-B Insecticidal 3-acylaminobenzanilides BAYER CROPSCIENCE AG 2012-09-05 CN claimed
EP-1814545-A4 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM LLC (BM) 2009-06-10 EP claimed
US-20080221192-A1 Compounds and Compositions as Protein Kinase Inhibitors IRM LLC (BM) 2008-09-11 US claimed
EP-1814545-A2 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM, LLC (BM) 2007-08-08 EP claimed
WO-2006052936-A2 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM LLC (BM) 2006-05-18 WO claimed
CN-1235886-C Method for preparing sulfhydyl-(m-benzamido) phenyl tetrazole HUAFENG CHEMICAL CO LTD NANTON (CN) 2006-01-11 CN claimed
EP-4705291-A1 IKK-ALPHA INHIBITORS Cancer Research Technology Limited (GB) 2026-03-11 EP disclosed
US-20250352542-A1 TRPV2 CHANNEL BLOCKERS AND USE THEREOF ICHILOV TECH LTD. (IL) 2025-11-20 US disclosed
EP-4551568-A1 TRPV2 CHANNEL BLOCKERS AND USE THEREOF Ichilov Tech Ltd. (IL) 2025-05-14 EP disclosed
CN-119816492-A TRPV2 channel blocker and use thereof 伊契洛夫科技有限公司 2025-04-11 CN disclosed
CN-119306730-A Cyclic ether modified 3-cyano-4-arylaminoquinoline derivative as well as preparation method and application thereof 河北医科大学 2025-01-14 CN disclosed
WO-2024228035-A1 IKK-ALPHA INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-11-07 WO disclosed
US-20240277852-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN DANA-FARBER CANCER INSTITUTE, INC. (US) 2024-08-22 US disclosed
US-4080321-A COLORFASTNESS HOECHST AKTIENGESELLSCHAFT (DT) 1978-03-21 US disclosed
US-4057518-A Process for the manufacture of heat resistant multicellular materials RHONE-POULENC INDUSTRIES (FR) 1977-11-08 US disclosed
US-4032532-A AZO DYES SANDOZ LTD. (CH) 1977-06-28 US disclosed
US-4013600-A STORAGE STABILITY RHONE-POULENC INDUSTRIES (FR) 1977-03-22 US disclosed
US-4010220-A AMINO COMPOUND, POLYURETHANE ELASTOMER RHONE-POULENC INDUSTRIES (FR) 1977-03-01 US disclosed
US-4007213-A Process for preparing 1-(N-β-cyanethylaminol-3-acylaminobenzenes HOECHST AKTIENGESELLSCHAFT (DT) 1977-02-08 US disclosed
US-3998803-A TEXTILES FIDELITY UNION TRUST COMPANY, EXECUTIVE TRUSTEE UNDER THE SANDOZ TRUST (US) 1976-12-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250352542-A1 TRPV2 CHANNEL BLOCKERS AND USE THEREOF TRPV2, TRPV1, TRPA1 KCNK3 171/4885KCNK9 264/4885PTGS1 130/4885
US-20240277852-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN PIP4K2A, PIP4K2C, PIP4K2B KCNK3 2122/4885KCNK9 2339/4885PTGS1 3789/4885
US-20080221192-A1 Compounds and Compositions as Protein Kinase Inhibitors BMX, FRK, PTK2B KCNK3 874/4885KCNK9 1165/4885PTGS1 3980/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.