Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 1.00 |
| ▸ | CDK7 | P50613 | 15/20 | 1.00 |
| ▸ | CDK1 | P06493 | 14/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 13/20 | 1.00 |
| ▸ | CCNH | P51946 | 13/20 | 1.00 |
| ▸ | CDK4 | P11802 | 13/20 | 1.00 |
| ▸ | CCNB1 | P14635 | 12/20 | 1.00 |
| ▸ | CCND1 | P24385 | 11/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 10/20 | 1.00 |
| ▸ | CDK9 | P50750 | 8/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 2/20 | 1.00 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.81 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.81 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6248828 | 1.00 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNH | |
| SCHEMBL3879278 | 1.00 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNH | |
| SCHEMBL6244174 | 1.00 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNH | |
| SCHEMBL6246011 | 1.00 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNH | |
| SCHEMBL4490773 | 0.93 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNH | |
| SCHEMBL4564826 | 0.93 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNH | |
| SCHEMBL4487335 | 0.93 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNH | |
| SCHEMBL4564827 | 0.93 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNH | |
| SCHEMBL4484946 | 0.92 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNH | |
| SCHEMBL4487926 | 0.92 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612079-B2 | 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612079-B2 | 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |