Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 1.00 |
| ▸ | CDK7 | P50613 | 16/20 | 1.00 |
| ▸ | CDK1 | P06493 | 16/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 15/20 | 1.00 |
| ▸ | CCNB1 | P14635 | 13/20 | 1.00 |
| ▸ | CCNH | P51946 | 13/20 | 1.00 |
| ▸ | CDK4 | P11802 | 12/20 | 1.00 |
| ▸ | CCND1 | P24385 | 12/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 8/20 | 1.00 |
| ▸ | CDK9 | P50750 | 5/20 | 0.87 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.87 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.74 |
| ▸ | CLK2 | P49760 | 2/20 | 0.74 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.74 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.74 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.74 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564827 | 1.00 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNB1 | |
| SCHEMBL4564826 | 1.00 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNB1 | |
| SCHEMBL4490773 | 1.00 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNB1 | |
| SCHEMBL13633351 | 0.93 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNB1 | |
| SCHEMBL6246011 | 0.93 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNB1 | |
| SCHEMBL6248828 | 0.93 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNB1 | |
| SCHEMBL6244174 | 0.93 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNB1 | |
| SCHEMBL3879278 | 0.93 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNB1 | |
| SCHEMBL4484946 | 0.91 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNB1 | |
| SCHEMBL4487926 | 0.91 | CDK2 (1.00) | CDK2CDK7CDK1CCNE1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612079-B2 | 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612079-B2 | 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612079-B2 | 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| WO-2007110649-A2 | PROCESS FOR THE PREPARATION OF 2,6,9-TRISUBSTITUTED PURINES | CYCLACEL LIMITED (GB) | 2007-10-04 | — | — | WO | disclosed |
| EP-1399446-B1 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | CYCLACEL LTD (GB) | 2005-08-03 | — | — | EP | disclosed |
| EP-1399446-A1 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | Cyclacel Limited (GB) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003002565-A1 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE N THE TREATMENT OF PROLIFERATIVE DISORDERS | CYCLACEL LIMITED (GB) | 2003-01-09 | — | — | WO | disclosed |