Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 1.00 |
| ▸ | CDK1 | P06493 | 16/20 | 1.00 |
| ▸ | CDK7 | P50613 | 15/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 13/20 | 1.00 |
| ▸ | CDK4 | P11802 | 13/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 12/20 | 1.00 |
| ▸ | CCNH | P51946 | 12/20 | 1.00 |
| ▸ | CCNB1 | P14635 | 12/20 | 1.00 |
| ▸ | CCND1 | P24385 | 11/20 | 1.00 |
| ▸ | CDK9 | P50750 | 7/20 | 0.81 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.81 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.81 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.81 |
| ▸ | CCNK | O75909 | 3/20 | 0.81 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.81 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.81 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.81 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.81 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.81 |
| ▸ | CLK2 | P49760 | 2/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17628584 | 1.00 | CDK2 (1.00) | CDK2CDK1CDK7CCNE1CDK4 | |
| SCHEMBL1378096 | 0.94 | CDK2 (0.89) | CDK2CDK1CDK7CCNE1CDK4 | |
| SCHEMBL1378255 | 0.91 | CDK2 (0.83) | CDK2CDK1CDK7CCNE1CDK4 | |
| SCHEMBL1375655 | 0.91 | CDK2 (0.83) | CDK2CDK1CDK7CCNE1CDK4 | |
| (Rs)-Roscovitine SCHEMBL172593 | 0.90 | CDK1 (1.00) | CDK2CDK1CDK7CCNE1CDK4 | |
| Seliciclib SCHEMBL94728 | 0.90 | CDK1 (1.00) | CDK2CDK1CDK7CCNE1CDK4 | |
| (S)-Roscovitine SCHEMBL29415376 | 0.90 | CDK1 (1.00) | CDK2CDK1CDK7CCNE1CDK4 | |
| (S)-Roscovitine SCHEMBL2907488 | 0.90 | CDK1 (1.00) | CDK2CDK1CDK7CCNE1CDK4 | |
| (Rs)-Roscovitine SCHEMBL15163619 | 0.90 | CDK1 (1.00) | CDK2CDK1CDK7CCNE1CDK4 | |
| SCHEMBL17628592 | 0.89 | CDK2 (0.80) | CDK2CDK1CDK7CCNE1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752629-B2 | Calcium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-08-25 | — | — | US | disclosed |
| US-10752629-B2 | Calcium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-08-25 | — | — | US | disclosed |
| US-20190084984-A1 | CALCIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-03-21 | — | — | US | disclosed |
| US-20190084984-A1 | CALCIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-03-21 | — | — | US | disclosed |
| US-10174031-B2 | Calcium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2019-01-08 | — | — | US | disclosed |
| US-10174031-B2 | Calcium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180009810-A1 | CALCIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-01-11 | — | — | US | disclosed |
| US-20180009810-A1 | CALCIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-01-11 | — | — | US | disclosed |
| US-9796714-B2 | Calcium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-10-24 | — | — | US | disclosed |
| US-9796714-B2 | Calcium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-10-24 | — | — | US | disclosed |
| US-9796714-B2 | Calcium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-10-24 | — | — | US | disclosed |
| US-20160090387-A1 | CALCIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-03-31 | — | — | US | disclosed |
| US-20160090387-A1 | CALCIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-03-31 | — | — | US | disclosed |
| US-20160090387-A1 | CALCIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-03-31 | — | — | US | disclosed |
| US-7612079-B2 | 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612079-B2 | 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009810-A1 | CALCIUM CHANNEL AGONISTS | CACNA1E, CACNA1C, CACNA1S | CDK2 3024/4885CDK1 2530/4885CDK7 2564/4885 |
| US-20190084984-A1 | CALCIUM CHANNEL AGONISTS | CACNA1E, CACNA1C, CACNA1S | CDK2 3024/4885CDK1 2530/4885CDK7 2564/4885 |
| US-20160090387-A1 | CALCIUM CHANNEL AGONISTS | CACNA1E, CACNA1C, CACNA1S | CDK2 3024/4885CDK1 2530/4885CDK7 2564/4885 |
| US-10174031-B2 | Calcium channel agonists | CACNA1E, CACNA1C, CACNA1S | CDK2 3024/4885CDK1 2530/4885CDK7 2564/4885 |
| US-10752629-B2 | Calcium channel agonists | CACNA1E, CACNA1C, CACNA1S | CDK2 3024/4885CDK1 2530/4885CDK7 2564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.