Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.89 |
| ▸ | CDK1 | P06493 | 17/20 | 0.89 |
| ▸ | CDK7 | P50613 | 17/20 | 0.89 |
| ▸ | CDK4 | P11802 | 15/20 | 0.89 |
| ▸ | CCNE1 | P24864 | 15/20 | 0.89 |
| ▸ | MAPK1 | P28482 | 14/20 | 0.89 |
| ▸ | CCNH | P51946 | 14/20 | 0.89 |
| ▸ | CCNB1 | P14635 | 13/20 | 0.89 |
| ▸ | CCND1 | P24385 | 13/20 | 0.89 |
| ▸ | CDK9 | P50750 | 10/20 | 0.80 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.80 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.80 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.80 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.80 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.71 |
| ▸ | CLK2 | P49760 | 2/20 | 0.71 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.71 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.71 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.71 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17628584 | 0.94 | CDK2 (1.00) | CDK2CDK1CDK7CDK4CCNE1 | |
| SCHEMBL1375655 | 0.94 | CDK2 (0.83) | CDK2CDK1CDK7CDK4CCNE1 | |
| SCHEMBL1378255 | 0.94 | CDK2 (0.83) | CDK2CDK1CDK7CDK4CCNE1 | |
| SCHEMBL13633363 | 0.94 | CDK2 (1.00) | CDK2CDK1CDK7CDK4CCNE1 | |
| SCHEMBL3749485 | 0.90 | CDK2 (0.86) | CDK2CDK1CDK7CDK4CCNE1 | |
| SCHEMBL14403894 | 0.89 | CDK1 (0.88) | CDK2CDK1CDK7CDK4CCNE1 | |
| SCHEMBL29829223 | 0.89 | CDK2 (1.00) | CDK2CDK1CDK7CDK4CCNE1 | |
| SCHEMBL1378920 | 0.89 | CDK2 (1.00) | CDK2CDK1CDK7CDK4CCNE1 | |
| SCHEMBL1374884 | 0.89 | CDK2 (1.00) | CDK2CDK1CDK7CDK4CCNE1 | |
| SCHEMBL3336119 | 0.89 | CDK2 (1.00) | CDK2CDK1CDK7CDK4CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4723858-B2 | — | — | 2011-07-13 | — | — | JP | claimed |
| JP-2006506341-A | — | — | 2006-02-23 | — | — | JP | claimed |
| EP-1529047-A2 | NEW PURINE DERIVATIVES | Cyclacel Limited (GB) | 2005-05-11 | — | — | EP | claimed |
| WO-2004016612-A2 | NEW PURINE DERIVATIVES | CYCLACEL LIMITED (GB) | 2004-02-26 | — | — | WO | claimed |
| EP-1951307-A2 | COMBINATION OF A CDK-INHIBITOR AND A HDAC-INHIBITOR | Cyclacel Limited (GB) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007054725-A2 | COMBINATION OF A CDK-INHIBITOR AND A HDAC-INHIBITOR | CYCLACEL LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |
| EP-1529047-A2 | NEW PURINE DERIVATIVES | Cyclacel Limited (GB) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004016612-A2 | NEW PURINE DERIVATIVES | CYCLACEL LIMITED (GB) | 2004-02-26 | — | — | WO | disclosed |