Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KCNA2 | P16389 | 1/20 | 0.48 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11416864 | 0.76 | AKR1B1 (0.69) | KMT2AKDM4EHPGDMEN1POLB | |
| SCHEMBL13638424 | 0.73 | ALDH1A1 (0.51) | KMT2ANPC1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL19002490 | 0.72 | ALDH1A1 (0.68) | KMT2AKDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL19354132 | 0.72 | KDM4E (0.51) | KMT2AKDM4EHPGDMEN1POLB | |
| SCHEMBL12894164 | 0.71 | MCL1 (0.51) | KMT2ANPC1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7459816 | 0.71 | MCL1 (0.56) | KMT2ANPC1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL24160929 | 0.71 | KDM4E (0.54) | KMT2AKDM4EHPGDMEN1POLB | |
| SCHEMBL18997404 | 0.71 | KDM4E (0.54) | KMT2AKDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL12894187 | 0.70 | MCL1 (0.50) | KMT2ANPC1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL12993677 | 0.70 | KDM4E (0.49) | KMT2AKDM4EHPGDSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622499-B2 | β-Benzyloxyaspartate derivatives with photosensitive groups | SUNTORY HOLDINGS LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-20070158175-A1 | (2S,3S)-3-Benzyloxy-N-[7-(carboxymethoxy) coumarin-4-ylmethoxy]carbonylaspartate; upon photoirradiation can produce compounds exhibiting a function of suppressing the glutamate uptake activity of L-glutamate transporters; use in treatment of neurological disorders and neurodegenerative conditions | SUNTORY HOLDINGS LIMITED (JP) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070158175-A1 | (2S,3S)-3-Benzyloxy-N-[7-(carboxymethoxy) coumarin-4-ylmethoxy]carbonylaspartate; upon photoirradiation can produce compounds exhibiting a function of suppressing the glutamate uptake activity of L-glutamate transporters; use in treatment of neurological disorders and neurodegenerative conditions | SLC1A1, SLC1A2, SLC1A3 | KMT2A 2960/4885NPC1 388/4885KDM4E 2999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.