Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.59 |
| ▸ | CCR2 | P41597 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528761 | 0.90 | ROCK2 (0.63) | ROCK2ROCK1CCR2 | |
| SCHEMBL4428205 | 0.86 | ROCK2 (0.61) | ROCK2ROCK1CCR2 | |
| SCHEMBL4428211 | 0.86 | ROCK2 (0.61) | ROCK2ROCK1CCR2 | |
| SCHEMBL659539 | 0.85 | ROCK2 (0.54) | ROCK2ROCK1CCR2 | |
| SCHEMBL10080113 | 0.85 | ROCK2 (0.57) | ROCK2ROCK1CCR2 | |
| SCHEMBL528598 | 0.85 | ROCK2 (0.54) | ROCK2ROCK1CCR2 | |
| SCHEMBL29862650 | 0.81 | ROCK2 (0.58) | ROCK2ROCK1CCR2 | |
| SCHEMBL5662572 | 0.81 | ROCK2 (0.58) | ROCK2ROCK1CCR2 | |
| SCHEMBL4477690 | 0.79 | ROCK2 (0.56) | ROCK2ROCK1CCR2 | |
| SCHEMBL13633467 | 0.79 | ROCK2 (0.75) | ROCK2ROCK1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615564-B2 | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-11-10 | — | — | US | disclosed |