Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 17/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1363194 | 0.97 | CHRM3 (0.46) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL1363440 | 0.94 | PDE4B (0.43) | CHRM3PDE4B | |
| SCHEMBL3430634 | 0.93 | CHRM3 (0.45) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL1364238 | 0.93 | PDE4B (0.44) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL13760158 | 0.92 | CHRM3 (0.41) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL1365292 | 0.92 | PDE4B (0.41) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL13760329 | 0.91 | CHRM3 (0.40) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL13760340 | 0.91 | CHRM3 (0.40) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL13760880 | 0.91 | PDE4B (0.44) | CHRM3CHRM2CHRM1PDE4B | |
| SCHEMBL1363909 | 0.91 | PDE4B (0.44) | CHRM3CHRM2CHRM1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067408-B2 | Dual pharmacophores—PDE4-muscarinic antagonistics | GLAXO GROUP LIMITED (GB) | 2011-11-29 | — | — | US | disclosed |