Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDAC2 | P45880 | 1/20 | 0.79 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13633700 | 0.93 | VDAC2 (0.68) | VDAC2SLC7A11HIF1ASMN1; SMN2NPSR1 | |
| SCHEMBL13633697 | 0.93 | VDAC2 (0.68) | VDAC2SLC7A11HIF1ASMN1; SMN2NPSR1 | |
| SCHEMBL13633727 | 0.92 | VDAC2 (0.67) | VDAC2SLC7A11HIF1ASMN1; SMN2NPSR1 | |
| SCHEMBL13751484 | 0.92 | VDAC2 (0.67) | VDAC2SLC7A11HIF1ASMN1; SMN2NPSR1 | |
| SCHEMBL27256133 | 0.91 | VDAC2 (0.70) | VDAC2SLC7A11HIF1ASMN1; SMN2NPSR1 | |
| SCHEMBL13633741 | 0.89 | VDAC2 (0.63) | VDAC2SLC7A11HIF1ASMN1; SMN2NPSR1 | |
| SCHEMBL13633724 | 0.89 | VDAC2 (0.63) | VDAC2SLC7A11HIF1ASMN1; SMN2NPSR1 | |
| SCHEMBL13633596 | 0.89 | VDAC2 (0.72) | VDAC2SLC7A11HIF1ASMN1; SMN2NPSR1 | |
| Erastin SCHEMBL22213543 | 0.88 | SLC7A11 (1.00) | VDAC2SLC7A11HIF1ALMNA | |
| Erastin SCHEMBL4457820 | 0.88 | SLC7A11 (1.00) | VDAC2SLC7A11HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615554-B2 | Erastin and erastin binding proteins, and uses thereof | PROLEXYS PHARMACEUTICALS, INC. (US) | 2009-11-10 | — | — | US | disclosed |
| US-7615554-B2 | Erastin and erastin binding proteins, and uses thereof | PROLEXYS PHARMACEUTICALS, INC. (US) | 2009-11-10 | — | — | US | disclosed |