Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923167 | 0.90 | P2RY12 (0.48) | P2RY12MAPTFBP1AKR1C3AKR1C2 | |
| SCHEMBL13633750 | 0.88 | P2RY12 (0.45) | P2RY12MAPTFBP1AKR1C3AKR1C2 | |
| SCHEMBL9923159 | 0.86 | P2RY12 (0.49) | P2RY12MAPTFBP1MEN1KMT2A | |
| SCHEMBL9922289 | 0.85 | P2RY12 (0.49) | P2RY12MAPTFBP1AKR1C3AKR1C2 | |
| SCHEMBL9923157 | 0.84 | P2RY12 (0.48) | P2RY12MAPTFBP1MEN1KMT2A | |
| SCHEMBL13638506 | 0.84 | P2RY12 (0.48) | P2RY12MAPTFBP1MEN1KMT2A | |
| SCHEMBL9923158 | 0.84 | P2RY12 (0.52) | P2RY12MAPTFBP1MEN1KMT2A | |
| SCHEMBL9922295 | 0.83 | P2RY12 (0.48) | P2RY12MAPTFBP1AKR1C3AKR1C2 | |
| SCHEMBL9920094 | 0.83 | P2RY12 (0.48) | P2RY12MAPTFBP1MEN1KMT2A | |
| SCHEMBL9923161 | 0.83 | P2RY12 (0.49) | P2RY12MAPTFBP1CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |