Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 5/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922289 | 0.91 | P2RY12 (0.49) | P2RY12FBP1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL14113531 | 0.89 | P2RY12 (0.39) | P2RY12FBP1LMNAPPARG | |
| SCHEMBL9923157 | 0.89 | P2RY12 (0.48) | P2RY12FBP1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL9923158 | 0.89 | P2RY12 (0.52) | P2RY12FBP1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL9923161 | 0.88 | P2RY12 (0.49) | P2RY12FBP1MAPTCASP3SENP8 | |
| SCHEMBL12177252 | 0.88 | FBP1 (0.43) | P2RY12FBP1MAPTMEN1KMT2A | |
| SCHEMBL9923159 | 0.88 | P2RY12 (0.49) | P2RY12FBP1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL9922294 | 0.88 | P2RY12 (0.47) | P2RY12FBP1MAPTMEN1KMT2A | |
| SCHEMBL12177307 | 0.87 | P2RY12 (0.47) | P2RY12FBP1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL9920083 | 0.87 | P2RY12 (0.49) | P2RY12FBP1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7358257-B2 | sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-04-15 | — | — | US | disclosed |