Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922609 | 0.90 | KCNH2 (0.38) | HRH3KCNH2RORCHTR3AALDH1A1 | |
| SCHEMBL9922832 | 0.90 | KCNH2 (0.37) | HRH3KCNH2RORCHTR3AALDH1A1 | |
| SCHEMBL9923249 | 0.89 | RORC (0.37) | HRH3RORCALDH1A1MAPK1MEN1 | |
| SCHEMBL9923251 | 0.88 | RORC (0.37) | RORCALDH1A1MAPK1MEN1LMNA | |
| SCHEMBL9922389 | 0.84 | MAPT (0.43) | KCNH2RORCALDH1A1MAPK1MEN1 | |
| SCHEMBL9922836 | 0.84 | MAPK14 (0.41) | KCNH2MEN1KMT2A | |
| SCHEMBL14228354 | 0.82 | KMT2A (0.39) | RORCALDH1A1MAPK1MEN1LMNA | |
| SCHEMBL9923250 | 0.82 | MAPK14 (0.44) | KMT2A | |
| SCHEMBL9922960 | 0.82 | KMT2A (0.40) | RORCALDH1A1MAPK1MEN1LMNA | |
| SCHEMBL9922959 | 0.82 | PTGER3 (0.41) | RORCALDH1A1MAPK1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |