Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 9/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200782 | 0.90 | P2RY12 (0.46) | P2RY12MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL12161710 | 0.89 | MEN1 (0.47) | P2RY12MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL12161697 | 0.89 | MAOB (0.46) | P2RY12MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL12177423 | 0.83 | STING1 (0.46) | P2RY12LMNASTING1MAPT | |
| SCHEMBL9922220 | 0.83 | MAPT (0.40) | MEN1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL12161715 | 0.81 | MEN1 (0.46) | P2RY12MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL14113780 | 0.81 | MEN1 (0.46) | P2RY12MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL9922392 | 0.80 | P2RY12 (0.42) | P2RY12MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL9922655 | 0.80 | P2RY12 (0.47) | P2RY12MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL13633811 | 0.80 | P2RY12 (0.42) | P2RY12MEN1KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |