Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922217 | 0.92 | P2RY12 (0.45) | P2RY12MEN1HTTKMT2ALMNA | |
| SCHEMBL14088508 | 0.90 | MEN1 (0.42) | P2RY12MEN1HTTKMT2ALMNA | |
| SCHEMBL9922639 | 0.89 | P2RY12 (0.42) | P2RY12MEN1HTTKMT2ALMNA | |
| SCHEMBL14228352 | 0.86 | CA12 (0.39) | P2RY12ITKALDH1A1CA12CA9 | |
| SCHEMBL12161716 | 0.82 | P2RY12 (0.44) | P2RY12MEN1HTTKMT2ALMNA | |
| SCHEMBL9922653 | 0.81 | P2RY12 (0.46) | P2RY12MEN1HTTKMT2ALMNA | |
| SCHEMBL13633804 | 0.80 | P2RY12 (0.43) | P2RY12MEN1HTTKMT2ALMNA | |
| SCHEMBL12161694 | 0.78 | ROCK1 (0.44) | P2RY12MEN1HTTKMT2ALMNA | |
| SCHEMBL9922962 | 0.76 | NAMPT (0.46) | P2RY12MEN1HTTKMT2ALMNA | |
| SCHEMBL13638644 | 0.76 | FBP1 (0.42) | MEN1HTTKMT2AFBP1ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |