Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923239 | 0.89 | HRH3 (0.37) | HRH3KCNH2PTGER3 | |
| SCHEMBL9923241 | 0.89 | HRH3 (0.36) | HRH3KCNH2PTGER3 | |
| SCHEMBL9922811 | 0.88 | PTGER3 (0.37) | HRH3PTGER3 | |
| SCHEMBL12161516 | 0.87 | PTGER3 (0.37) | HRH3PTGER3 | |
| SCHEMBL9922365 | 0.85 | PTGER3 (0.40) | PTGER3 | |
| SCHEMBL12177102 | 0.82 | HRH3 (0.39) | HRH3KCNH2PTGER3 | |
| SCHEMBL9923245 | 0.82 | CRHBP (0.39) | PTGER3 | |
| SCHEMBL9922192 | 0.82 | PTGER3 (0.44) | PTGER3 | |
| SCHEMBL9922203 | 0.81 | P2RY12 (0.40) | PTGER3 | |
| SCHEMBL9922838 | 0.81 | SMN1; SMN2 (0.39) | PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |