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CRHBP

Corticotropin-releasing factor-binding protein · P24387 · CRHBP on Sugi Atlas →

112,066 patent compounds predicted against CRHBP, 73,236 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL35679 SCHEMBL35679 1.00 2/20
SCHEMBL35765 SCHEMBL35765 1.00 2/20
SCHEMBL35801 SCHEMBL35801 1.00 2/20
SCHEMBL76331 SCHEMBL76331 1.00 2/20
SCHEMBL35510 SCHEMBL35510 0.85 2/20
SCHEMBL35680 SCHEMBL35680 0.85 2/20
SCHEMBL35766 SCHEMBL35766 0.85 2/20
SCHEMBL35802 SCHEMBL35802 0.85 2/20
SCHEMBL8518 SCHEMBL8518 0.82 2/20
Escin Ia Escin Ia (SCHEMBL167245) 0.76 2/20
SCHEMBL9351 SCHEMBL9351 0.65 2/20
Ibuproxam Ibuproxam (SCHEMBL24896) 0.63 2/20
SCHEMBL35655 SCHEMBL35655 0.63 2/20
SCHEMBL169824 SCHEMBL169824 0.61 2/20
SCHEMBL112074 SCHEMBL112074 0.60 2/20
SCHEMBL167524 SCHEMBL167524 0.59 2/20
SCHEMBL160430 SCHEMBL160430 0.57 2/20
SCHEMBL163325 SCHEMBL163325 0.56 2/20
SCHEMBL151094 SCHEMBL151094 0.56 2/20
Pheneturide Pheneturide (SCHEMBL35066) 0.55 2/20

Clinical trials — most relevant to CRHBP by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Counteracting Deleterious Metabolic Glucocorticoid Effects With Metformin PHASE4COMPLETED
Prednisolone Versus Vigabatrin in the First-line Treatment of Infantile Spasms PHASE3WITHDRAWN
Novel Therapeutics in Posttraumatic Stress Disorder (PTSD): A Randomized Clinical Trial of Mifepristone PHASE2COMPLETED
ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study) PHASE2COMPLETED
A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis PHASE2UNKNOWN
Efficacy of Intrathecal Clonidine Versus Neostigmine as Adjuvants to Bupivacaine on Postoperative Maternal and Fetal Outcomes After Elective Cesarean Section PHASE1UNKNOWN
Vagal Nerve Stimulation for Intestinal Barrier Dysfunction in Healthy Volunteers PHASE1COMPLETED
Stress, Hormones, and Eating EARLY_PHASE1COMPLETED
Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency nanCOMPLETED
Measurement of Pituitary Volume and Hormonal Changes in Patients With Post-traumatic Stress Disorder nanCOMPLETED
A Proof-of-concept Study Evaluating the Microbiota-gut-brain Axis nanRECRUITING
IGF and Other Neurotrophic Factors in Patients With Dementia nanCOMPLETED
Cue-based Tactile Stimulation and Infant Stress Reactivity nanCOMPLETED
Measurement of Hormone Levels in Patients Receiving 17-HPC for Preterm Delivery nanCOMPLETED
Corticotropin Releasing Hormone (CRH) Responsiveness in Children With Functional Dyspepsia nanWITHDRAWN
Modified Desmopressin (mDesmo) Using Cold-Kit for PET/CT nanRECRUITING
Multi-level Molecular Profiling of High Acute Stress: a Clinical Study nanUNKNOWN
Effects of Manual Therapy in Fibromyalgia Syndrome nanCOMPLETED
The Interplay Between Addiction to Tobacco Smoking and Sleep Quality Among Healthy Adults nanUNKNOWN
Direct and Cross Effects of Adaptation to Systemic Hyperthermia: Impact on Quality of Life, Neurohormonal and Psychophysiological Human Status nanCOMPLETED
DDAVP for Pituitary Adenoma nanRECRUITING
Effectiveness of Guided Imagery Intervention on Factors Associated With Maternal Stress and Preterm Birth nanCOMPLETED
Molecular Pathways Involved in Knee Pain nanCOMPLETED
Effects of Mindfulness Meditation on Hemodialysis Patients nanCOMPLETED
Examination of Brain Serotonin Receptors in Patients With Mood Disorders nanCOMPLETED
Re-nutrition in Severe Anorexia Nervosa nanCOMPLETED
Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism nanUNKNOWN
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein nanCOMPLETED
Rehabilitation Program in Patients With Acromegaly nanUNKNOWN
Copeptin for Risk Stratification in Acute Stroke Patients: the CoRisk Study nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CRHBP binder may also engage these)

ProteinNameSimilarity
Q60571 — 1.000 Q60571 →
Q28557 — 0.997 Q28557 →
P24388 — 0.996 P24388 →
Q91653 — 0.991 Q91653 →
Q0VCN6 — 0.974 Q0VCN6 →
Q9H4D0 — 0.973 Q9H4D0 →
Q8R4K8 — 0.973 Q8R4K8 →
Q8R553 — 0.971 Q8R553 →
O94985 — 0.970 O94985 →
Q6PE55 — 0.970 Q6PE55 →
Q8VDA1 — 0.970 Q8VDA1 →
Q99JH7 — 0.970 Q99JH7 →
A7E2Z9 — 0.969 A7E2Z9 →
Q24025 — 0.969 Q24025 →
Q6NZZ3 — 0.969 Q6NZZ3 →
Q9ER65 — 0.968 Q9ER65 →
Q2PFX1 — 0.968 Q2PFX1 →
Q9BQT9 — 0.968 Q9BQT9 →
Q5NDE7 — 0.968 Q5NDE7 →
P28825 — 0.968 P28825 →
Q61592 — 0.967 Q61592 →
Q5R9Q9 — 0.967 Q5R9Q9 →
MEP1A Meprin A subunit alpha 0.967 landscape →
Q68CR1 — 0.966 Q68CR1 →
B0S5G3 — 0.966 B0S5G3 →
Q80TS8 — 0.966 Q80TS8 →
Q91713 — 0.966 Q91713 →
F1R520 — 0.966 F1R520 →
O57472 — 0.966 O57472 →
Q9EPL2 — 0.966 Q9EPL2 →