Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 12/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634964 | 0.94 | HTR4 (0.49) | HTR4ADRA1BCHRM4CHRM5ADRA2C | |
| SCHEMBL13634965 | 0.90 | HTR4 (0.46) | HTR4ADRA1BCHRM4CHRM5ADRA2C | |
| SCHEMBL13634894 | 0.85 | HTR4 (0.51) | HTR4ADRA1BCHRM4CHRM5ADRA2C | |
| SCHEMBL13634963 | 0.83 | HTR4 (0.61) | HTR4ADRA1BCHRM4CHRM5ADRA2C | |
| SCHEMBL13634543 | 0.82 | HTR4 (0.47) | HTR4ADRA1BCHRM4CHRM5ADRA2C | |
| SCHEMBL13634825 | 0.81 | HTR4 (0.49) | HTR4ADRA1BCHRM4CHRM5ADRA2C | |
| SCHEMBL13635104 | 0.81 | HTR4 (0.56) | HTR4ADRA1BCHRM4CHRM5ADRA2C | |
| SCHEMBL12377356 | 0.80 | HTR4 (0.53) | HTR4ADRA1BCHRM4CHRM5ADRA2C | |
| SCHEMBL14194645 | 0.78 | HTR4 (0.48) | HTR4ADRA1BCHRM4CHRM5ADRA2C | |
| SCHEMBL14194928 | 0.78 | HTR4 (0.48) | HTR4ADRA1BCHRM4CHRM5ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141575-A1 | INHIBITORS OF PLK | CHROMA THERAPEUTICS LTD. (GB) | 2009-11-26 | — | — | WO | disclosed |