Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634479 | 0.97 | NPC1 (0.57) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL15983801 | 0.90 | NPC1 (0.73) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13634496 | 0.83 | NPC1 (0.50) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13634682 | 0.83 | NPC1 (0.50) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13638984 | 0.81 | TAS1R3 (0.79) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13162940 | 0.81 | NPC1 (0.66) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4176567 | 0.81 | TAS1R3 (0.79) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL14328428 | 0.78 | NPC1 (0.58) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13638898 | 0.78 | TAS1R3 (0.74) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13164078 | 0.78 | NPC1 (0.61) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |