Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.33 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.33 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.33 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634836 | 1.00 | IRAK4 (0.37) | IRAK4JAK2JAK1GLSPIN1 | |
| SCHEMBL13634912 | 0.95 | IRAK4 (0.38) | IRAK4JAK2JAK1DRD4GRM2 | |
| SCHEMBL13638950 | 0.95 | IRAK4 (0.36) | IRAK4JAK2JAK1PIN1GRM2 | |
| SCHEMBL13638889 | 0.95 | IRAK4 (0.36) | IRAK4JAK2JAK1PIN1GRM2 | |
| SCHEMBL13634556 | 0.94 | IRAK4 (0.37) | IRAK4JAK2JAK1GLSDRD4 | |
| SCHEMBL13634866 | 0.91 | IRAK4 (0.39) | IRAK4JAK2JAK1DRD4GRM2 | |
| SCHEMBL13634549 | 0.91 | IRAK4 (0.39) | IRAK4JAK2JAK1DRD4GRM2 | |
| SCHEMBL13634733 | 0.90 | IRAK4 (0.36) | IRAK4JAK2JAK1GRM2KMT2A | |
| SCHEMBL13638778 | 0.90 | IRAK4 (0.37) | IRAK4JAK2JAK1GRM2PIM1 | |
| SCHEMBL13634799 | 0.89 | IRAK4 (0.41) | IRAK4JAK2JAK1GRM2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |