Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13635159 | 0.92 | P2RY12 (0.60) | P2RY12NAMPTCNR1TP53MAPT | |
| SCHEMBL13635059 | 0.91 | P2RY12 (0.61) | P2RY12NAMPTTP53MAPTROCK2 | |
| SCHEMBL13635261 | 0.90 | P2RY12 (0.64) | P2RY12TP53MAPTRECQLHSP90AA1 | |
| SCHEMBL13635117 | 0.89 | P2RY12 (0.62) | P2RY12NAMPTTP53MAPTRECQL | |
| SCHEMBL13635077 | 0.89 | P2RY12 (0.64) | P2RY12NAMPTCNR1TP53MAPT | |
| SCHEMBL13634804 | 0.88 | P2RY12 (0.59) | P2RY12NAMPTTP53MAPTRECQL | |
| SCHEMBL13634834 | 0.87 | P2RY12 (0.62) | P2RY12TP53MAPTRECQLHSP90AA1 | |
| SCHEMBL13635072 | 0.87 | P2RY12 (0.64) | P2RY12TP53MAPTHSP90AA1RXFP1 | |
| SCHEMBL13635048 | 0.87 | P2RY12 (0.64) | P2RY12TP53MAPTRECQLHSP90AA1 | |
| SCHEMBL13635053 | 0.87 | P2RY12 (0.58) | P2RY12NAMPTTP53MAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1668002-B1 | 2,4-DIOXO-3-QUINAZOLINYLARYL SULFONYLUREAS | PORTOLA PHARM INC (US) | 2009-11-11 | — | — | EP | disclosed |