Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 13/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13635050 | 0.91 | P2RY12 (0.48) | P2RY12CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13635261 | 0.91 | P2RY12 (0.64) | P2RY12KMT2AMEN1GAA | |
| SCHEMBL13635282 | 0.89 | P2RY12 (0.60) | P2RY12CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13635059 | 0.89 | P2RY12 (0.61) | P2RY12CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13635072 | 0.88 | P2RY12 (0.64) | P2RY12CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13635048 | 0.88 | P2RY12 (0.64) | P2RY12CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13635117 | 0.88 | P2RY12 (0.62) | P2RY12KMT2APOLBTHRBMEN1 | |
| SCHEMBL13635077 | 0.88 | P2RY12 (0.64) | P2RY12POLBNAMPTALDH1A1GAA | |
| SCHEMBL13635110 | 0.87 | P2RY12 (0.66) | P2RY12KMT2AMEN1GAA | |
| SCHEMBL13635168 | 0.87 | P2RY12 (0.61) | P2RY12KMT2AMEN1NAMPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1668002-B1 | 2,4-DIOXO-3-QUINAZOLINYLARYL SULFONYLUREAS | PORTOLA PHARM INC (US) | 2009-11-11 | — | — | EP | disclosed |