Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376208 | 0.85 | KDM4E (0.54) | MAPK14 | |
| SCHEMBL4380067 | 0.82 | MAPK14 (0.81) | MAPK14 | |
| SCHEMBL13635200 | 0.78 | MAPK14 (0.45) | MAPK14 | |
| SCHEMBL4374258 | 0.77 | KDM4E (0.47) | MAPK14 | |
| SCHEMBL3522590 | 0.76 | MAPK14 (0.56) | MAPK14 | |
| SCHEMBL4380789 | 0.76 | NPSR1 (0.47) | MAPK14 | |
| SCHEMBL13635902 | 0.75 | MAPK14 (0.49) | MAPK14 | |
| SCHEMBL4379371 | 0.73 | MAPK14 (0.80) | MAPK14 | |
| SCHEMBL4376670 | 0.73 | MAPK14 (0.83) | MAPK14 | |
| SCHEMBL4381120 | 0.73 | MAPK14 (0.83) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |