Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376213 | 0.80 | MAPK14 (0.45) | MAPK14GSK3BBACE1ROCK2MAPK12 | |
| SCHEMBL13635776 | 0.79 | MAPK14 (0.48) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6471335 | 0.73 | MAPK14 (0.47) | MAPK14GSK3BBACE1ROCK2MAPK12 | |
| SCHEMBL29594177 | 0.72 | MAPK14 (0.68) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL4376529 | 0.72 | MAPK14 (0.68) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL3526705 | 0.67 | MAPK14 (0.48) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL4468565 | 0.64 | MAPK14 (0.50) | MAPK14GSK3BBACE1 | |
| SCHEMBL4376549 | 0.64 | MAPK14 (0.52) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL27699486 | 0.63 | TYR (0.43) | — | |
| SCHEMBL13610118 | 0.62 | GSK3B (0.47) | MAPK14GSK3BBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |