Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.65 |
| ▸ | KDR | P35968 | 7/20 | 0.64 |
| ▸ | AXL | P30530 | 5/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
| ▸ | KIT | P10721 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | MERTK | Q12866 | 2/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3555116 | 0.86 | MET (0.74) | METKDRAXLRETKIT | |
| SCHEMBL3552329 | 0.84 | MET (0.69) | METKDRAXLRETKIT | |
| SCHEMBL1136977 | 0.83 | MET (0.73) | METKDRAXLPDGFRAFLT3 | |
| SCHEMBL16136597 | 0.81 | MET (0.67) | METKDRAXLRETKIT | |
| SCHEMBL3613361 | 0.80 | MET (0.62) | METKDRAXLRETKIT | |
| SCHEMBL3491557 | 0.80 | AXL (0.58) | METKDRAXLRETKIT | |
| SCHEMBL3555603 | 0.80 | MET (0.62) | METKDRAXLRETKIT | |
| SCHEMBL18256939 | 0.80 | MET (0.82) | METKDRAXLRETKIT | |
| SCHEMBL12363316 | 0.79 | MET (0.73) | METKDRAXLRETKIT | |
| SCHEMBL3555014 | 0.79 | MET (0.62) | METKDRAXLRETKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119706-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE | Eisai R&D Management Co., Ltd. (JP) | 2009-11-18 | — | — | EP | disclosed |