SCHEMBL13635327

SCHEMBL13635327

Bc1c(OCc2ccco2)cc(C)n(-c2c(F)cccc2F)c1=O

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 19/20 0.50
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4380100 0.87 MAPK14 (0.66) MAPK14
SCHEMBL13610867 0.72 MAPK14 (0.57) MAPK14
SCHEMBL3526202 0.71 MAPK14 (0.41) MAPK14
SCHEMBL13635214 0.70 MAPK14 (0.55) MAPK14
SCHEMBL4378496 0.68 MAPK14 (0.75) MAPK14
SCHEMBL4382467 0.67 MAPK14 (1.00) MAPK14
SCHEMBL4378481 0.66 MAPK14 (1.00) MAPK14
SCHEMBL4382666 0.65 MAPK14 (0.62) MAPK14
SCHEMBL4380105 0.64 MAPK14 (0.80) MAPK14
SCHEMBL13603179 0.64 MAPK14 (0.80) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1490064-B1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE PHARMACIA CORP (US) 2009-11-18 EP disclosed