Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | AGXT | P21549 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380696 | 0.87 | MAPK14 (0.56) | MAPK14 | |
| SCHEMBL4376611 | 0.87 | MAPK14 (0.57) | MAPK14MAOB | |
| SCHEMBL6472707 | 0.78 | PTGER1 (0.44) | MAPK14PTGER1 | |
| SCHEMBL6472148 | 0.78 | MAPK14 (0.42) | MAPK14PTGER1 | |
| SCHEMBL6474781 | 0.77 | ALDH1A1 (0.45) | MAPK14PTGER1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL4380236 | 0.77 | MAOB (0.52) | MAPK14MAOBIDO1AGXTCYP1A1 | |
| SCHEMBL6471254 | 0.76 | MAPK14 (0.44) | MAPK14PTGER1 | |
| SCHEMBL6472388 | 0.76 | PTGER1 (0.47) | MAPK14MAOBPTGER1 | |
| SCHEMBL6471879 | 0.76 | PTGER1 (0.47) | MAPK14MAOBPTGER1 | |
| SCHEMBL6471334 | 0.76 | MAPK14 (0.39) | MAPK14PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |