Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.59 |
| ▸ | AXL | P30530 | 12/20 | 0.59 |
| ▸ | MERTK | Q12866 | 9/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | KIT | P10721 | 2/20 | 0.58 |
| ▸ | FLT3 | P36888 | 2/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.58 |
| ▸ | TEK | Q02763 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | HCK | P08631 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL139145 | 0.92 | MET (0.59) | METAXLMERTKKDRRET | |
| Hydrochloric Acid SCHEMBL3560789 | 0.91 | MET (0.58) | METAXLMERTKKDRRET | |
| SCHEMBL14742746 | 0.90 | MET (0.54) | METAXLMERTKKDRRET | |
| SCHEMBL3555116 | 0.88 | MET (0.74) | METAXLKDRRETKIT | |
| SCHEMBL3553737 | 0.86 | MET (0.56) | METAXLMERTKKDRRET | |
| SCHEMBL139114 | 0.86 | MET (0.74) | METAXLMERTKKDRRET | |
| SCHEMBL3628572 | 0.86 | MET (0.56) | METAXLMERTKKDRRET | |
| SCHEMBL1890132 | 0.86 | CDK8 (0.63) | METKDRFLT3KCNH2PDGFRA | |
| SCHEMBL13635722 | 0.83 | MET (0.53) | METAXLMERTKKDRRET | |
| SCHEMBL22750206 | 0.81 | AXL (0.71) | METAXLMERTKKDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119706-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE | Eisai R&D Management Co., Ltd. (JP) | 2009-11-18 | — | — | EP | disclosed |