Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4383534 | 0.85 | MAPK14 (0.59) | MAPK14 | |
| SCHEMBL3518438 | 0.77 | MAPK14 (0.49) | MAPK14 | |
| SCHEMBL4377968 | 0.76 | GRIN1 (0.45) | MAPK14GRIN1GRIN2B | |
| SCHEMBL4380789 | 0.76 | NPSR1 (0.47) | MAPK14GRIN1GRIN2BGABRA1GABRA5 | |
| SCHEMBL3525752 | 0.74 | MAPK14 (0.44) | MAPK14GRIN1GRIN2B | |
| SCHEMBL3522901 | 0.74 | MAPK14 (0.54) | MAPK14 | |
| SCHEMBL4376242 | 0.73 | MAPK14 (0.65) | MAPK14 | |
| SCHEMBL4381130 | 0.73 | MAPK14 (0.72) | MAPK14 | |
| SCHEMBL4390072 | 0.73 | MAPK14 (0.48) | MAPK14GRIN1GRIN2B | |
| SCHEMBL13635178 | 0.73 | MAPK14 (0.56) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |