Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | AOC3 | Q16853 | 7/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CERT1 | Q9Y5P4 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16622111 | 1.00 | LMNA (0.57) | LMNAAOC3RIPK1KDM4EL3MBTL1 | |
| SCHEMBL16622108 | 1.00 | LMNA (0.57) | LMNAAOC3RIPK1KDM4EL3MBTL1 | |
| SCHEMBL16211206 | 0.89 | KDM4E (0.54) | LMNAAOC3RIPK1KDM4EL3MBTL1 | |
| SCHEMBL2638248 | 0.86 | AOC3 (0.50) | LMNAAOC3RIPK1KDM4EALDH1A1 | |
| SCHEMBL29238229 | 0.85 | CERT1 (0.51) | LMNARIPK1KDM4EALDH1A1CERT1 | |
| SCHEMBL4957871 | 0.83 | LMNA (0.68) | LMNAAOC3RIPK1KDM4EL3MBTL1 | |
| SCHEMBL540695 | 0.83 | LMNA (0.67) | LMNAAOC3RIPK1KDM4EL3MBTL1 | |
| SCHEMBL28617318 | 0.83 | LMNA (0.67) | LMNAAOC3RIPK1KDM4EL3MBTL1 | |
| SCHEMBL1295513 | 0.83 | LMNA (0.67) | LMNAAOC3RIPK1KDM4EL3MBTL1 | |
| SCHEMBL348229 | 0.83 | LMNA (0.67) | LMNAAOC3RIPK1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304451-B2 | Histone deacetylase and tubulin deacetylase inhibitors | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-11-06 | — | — | US | disclosed |
| US-20090209590-A1 | Histone Deacetylase and Tubulin Deacetylase Inhibitors | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209590-A1 | Histone Deacetylase and Tubulin Deacetylase Inhibitors | HDAC6, HDAC1, HDAC5 | LMNA 2250/4885AOC3 3599/4885RIPK1 1944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.