Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.61 |
| ▸ | RAF1 | P04049 | 7/20 | 0.45 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2256670 | 0.81 | MET (0.74) | METRAF1KDRMAPK3 | |
| SCHEMBL1136853 | 0.79 | MET (0.67) | METRAF1KDRMAPK3BRAF | |
| SCHEMBL1137024 | 0.76 | MET (0.73) | MET | |
| SCHEMBL1136770 | 0.74 | MET (0.64) | METKDRHCK | |
| SCHEMBL4335417 | 0.73 | MET (0.60) | METRAF1KDRMAPK3BRAF | |
| SCHEMBL2256662 | 0.71 | MET (0.62) | METRAF1KDRMAPK3BRAF | |
| SCHEMBL4337564 | 0.70 | MET (0.62) | METRAF1KDR | |
| SCHEMBL1137007 | 0.70 | MET (0.59) | METRAF1KDRMAPK3BRAF | |
| SCHEMBL23999220 | 0.70 | MET (0.76) | METKDR | |
| SCHEMBL1136765 | 0.69 | RAF1 (0.72) | METRAF1KDRMAPK3BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119706-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE | Eisai R&D Management Co., Ltd. (JP) | 2009-11-18 | — | — | EP | disclosed |