Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.57 |
| ▸ | CCND1 | P24385 | 5/20 | 0.57 |
| ▸ | CDK2 | P24941 | 5/20 | 0.57 |
| ▸ | CCND3 | P30281 | 5/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858040 | 0.88 | CDK4 (0.60) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL2864604 | 0.87 | RAB9A (0.54) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL4341430 | 0.85 | CDK4 (0.51) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL2861022 | 0.84 | KDR (0.50) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL4340622 | 0.84 | KMT2A (0.52) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL4341021 | 0.84 | MAPT (0.49) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL4336438 | 0.83 | CTSA (0.49) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL4328980 | 0.83 | CDK4 (0.49) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL4331277 | 0.81 | MAPK1 (0.47) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL4333955 | 0.79 | KDM4E (0.56) | NPC1RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |