SCHEMBL13635788

SCHEMBL13635788

Cc1cc(OCc2ccc(P)cc2F)c(Cl)c(=O)n1Cc1cc[nH]n1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 19/20 0.51
MAPKAPK2 P49137 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4384555 0.90 MAPK14 (0.61) MAPK14
Tert-Butyl Formate SCHEMBL28752331 0.83 MAPK14 (0.54) MAPK14MAPKAPK2
SCHEMBL4374149 0.79 MAPK14 (0.67) MAPK14
SCHEMBL4384930 0.75 MAPK14 (0.61) MAPK14MAPKAPK2
SCHEMBL3524169 0.74 MAPK14 (0.43) MAPK14
SCHEMBL4384623 0.74 MAPK14 (0.64) MAPK14MAPKAPK2
SCHEMBL13635313 0.73 MAPK14 (0.62) MAPK14MAPKAPK2
SCHEMBL6505318 0.73 MAPK14 (0.59) MAPK14
SCHEMBL6498827 0.73 MAPK14 (0.51) MAPK14
SCHEMBL4382685 0.72 MAPK14 (0.66) MAPK14MAPKAPK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1490064-B1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE PHARMACIA CORP (US) 2009-11-18 EP disclosed